IgA Nephropathy (Berger’s Disease) - Kidney disease - too much protein in the kidney

 IgA Nephropathy (Berger’s Disease)

IgA nephropathy is a chronic kidney disease where a protein called Immunoglobulin A (IgA) builds up in the kidneys, causing inflammation and damage over time.

WHAT HAPPENS IN THE BODY

IgA normally helps fight infections.

In this condition, IgA deposits in the kidney filters (glomeruli) → leading to inflammation → which can gradually reduce the kidneys’ ability to filter waste.

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WHO IS AT RISK

• More common in young adults

• Slightly more common in men

• Can run in families

• Higher risk in some ethnic groups (e.g., Asian, Caucasian)

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COMMON SYMPTOMS

Some people may have no symptoms early

When symptoms appear, they may include:

• Blood in urine (tea-colored or cola-colored)

• Foamy urine (protein in urine)

• Swelling in hands, feet, or face

• High blood pressure

• Fatigue

Often appears after a respiratory infection (cold, sore throat)

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CAUSE / TRIGGERS

Exact cause is not fully known, but linked to:

• Abnormal immune response

• Infections (respiratory or GI)

• Genetics

• Liver disease (in some cases)

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HOW IT PROGRESSES

IgA nephropathy can vary:

• Some people remain stable for years

• Others may develop chronic kidney disease (CKD)

• In severe cases → kidney failure

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DIAGNOSIS

• Urine test → blood & protein

• Blood test → kidney function (creatinine, eGFR)

• Kidney biopsy → confirms diagnosis

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TREATMENT

There is no single cure, but treatment helps slow progression:

1. Blood Pressure Control (VERY important)

• ACE inhibitors / ARBs

2. Reduce Protein Loss

• Medications to protect kidneys

3. Lifestyle Changes

• Low-salt diet

• Manage weight

• Control blood sugar (if diabetic)

4. In Some Cases:

• Steroids or immunosuppressants

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IMPORTANT

IgA nephropathy can be silent early, so regular lab monitoring is key.

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LIFESTYLE & CARE TIPS

• Monitor blood pressure regularly

• Limit salt intake

• Stay hydrated

• Avoid excessive NSAIDs (can worsen kidney damage)

• Follow up with your doctor

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KEY MESSAGE

Early detection matters

Control BP = protect your kidneys

Regular labs can catch problems early